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Glo1 inducer peer-reviewed publications

You are here: | Glo1 inducer peer-reviewed publications

Xue, M., Weickert, M.O., Qureshi, S., Kandala, N.-B., Anwar, A., Waldron, M., Shafie, A., Messenger, D., Fowler, M., Jenkins, G., Rabbani, N. and Thornalley, P.J. (2016) Improved glycemic control and vascular function in overweight and obese subjects by glyoxalase 1 inducer formulation. Diabetes 65, 2282 – 2294.

Rabbani, N., Xue, M. and Thornalley, P.J. (2016) Methylglyoxal-induced dicarbonyl stress in ageing and disease – first steps towards glyoxalase 1-based treatments. Clin. Sci. 130, 1677–1696

Rabbani, N. and Thornalley, P.J. (2019) Glyoxalase 1 modulation in obesity and diabetes. Antioxidants and Redox Signalling 30, 354–374.

Irshad, Z., Xue, M., Ashour, A., Larkin, J.R., Thornalley, P.J. and Rabbani, N. (2019) Activation of the unfolded protein response of endothelial cells in high glucose by methylglyoxal. Scientific Reports 9, 7889

Rabbani, N. and Thornalley, P.J. (2019) Hexokinase-2 glycolytic overload in diabetes and ischemia-reperfusion injury. Trends in Endocrinology & Metabolism 30, 419 – 431.

Ashour, A., Xue, M., Al-Motawa, M.S., Thornalley, P. J. and Rabbani, N. (2020) Glycolytic overload-driven dysfunction of periodontal ligament fibroblasts in high glucose concentration, corrected by glyoxalase 1 inducer. BMJ Open Diabetes Research & Care. 8, e001458.

Rabbani, N., Xue, M. and Thornalley, P.J. (2021) Dicarbonyl stress, protein glycation and the unfolded protein response. Glycoconjugate J. 38, 331 – 334.

Rabbani, N., Xue, M., Weickert, M.O. and Thornalley, P.J. (2021) Reversal of insulin resistance in overweight and obese subjects by trans-resveratrol and hesperetin combination – link to dysglycemia, blood pressure, dyslipidemia and low-grade inflammation.  Nutrients 13, 237.

Rabbani, N., Xue, M. and Thornalley, P.J. (2022) Hexokinase-2-linked glycolytic overload and unscheduled glycolysis – driver of insulin resistance and development of vascular complications of diabetes. Internat J. Molec. Sci. 23, 2165.

Rabbani, N. and Thornalley, P.J. (2022) Emerging glycation-based therapeutics – glyoxalase 1 inducers and glyoxalase 1 inhibitors. Internat J. Molec. Sci. 23, 2453

Xue, M., Rabbani, N. and Thornalley, P.J. (2024) Increased cellular protein modification by methylglyoxal activates three sensors of the unfolded protein response. Redox Biol. 65, 103025.

Rabbani, N. and Thornalley, P.J. (2024) Hexokinase-linked glycolytic overload and unscheduled glycolysis in hyperglycemia-induced pathogenesis in insulin resistance, beta-cell glucotoxicity and diabetic vascular complications. Frontiers in Endocrinology, 14, 1268308

Rabbani, N. and Thornalley, P.J. (2024) Unraveling the impaired incretin effect in obesity and type 2 diabetes: key role of hyperglycemia-induced unscheduled glycolysis and glycolytic overload. Diabetes Res. Clin. Pract., 217, 111905

Xue, M., Rabbani, N. and Thornalley, P.J. (2025) Glyoxalase 1 inducer, trans-resveratrol and hesperetin – dietary supplement with multi-modal health benefits. Antioxidants 14, 956.

Wentzel, P., Xue, M., Rabbani, N., Eriksson, U.J. and Thornalley, P.J. (2025) Overload of glucose metabolism as initiating factor in diabetic embryopathy and prevention by dietary supplement. Antioxidants 14, 1022

Rabbani, N. and Thornalley, P.J. (2025) Molecular mechanisms of metabolic dysfunction-associated steatotic liver disease (MASLD): functional analysis of glucose and fructose metabolism pathways. Clinical Science 139, 1–25.

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